Multiple sclerosis, 10 million for personalized therapies
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Feed artificial intelligence all the information about the disease, from blood tests to magnetic resonance images, and ask how the disease will evolve, what the responses to drugs could be. This is the purpose of CLAIMS, acronym of Clinical impact through AI-assisted MS dear, which aims to create a platform to make multiple sclerosis treatment ever more personalized. Because every patient is different, the manifestations of the disease and their needs are different. The project will receive funding of nearly 10 million euros over the next four years from the European Innovative Health Initiative and will be led by an international consortium led by the Charité – Universitätsmedizin, one of Berlin’s major university hospitals.
Multiple sclerosis and leukodystrophies, the diagnosis is made with artificial intelligence
by Elisa Manacorda
Train AI, with the help of patients
15 public and private partners will contribute to the development of the AI platform, including hospitals, universities, companies and foundations from nine countries, including Italy. “With CLAIMS we want to further personalize the treatment of people with MS – says Friedemann Paul, project coordinator -. We plan to develop predictive models that can predict the course of the disease for each individual patient based on their individual data and simulate the effects of different types of treatments. Patient involvement will be a crucial element.” Predicting the course of the disease and the effects of drugs could in fact allow experts to optimize therapeutic choices.
The algorithms that will make up the platform will be trained using patient clinical data, including the results of MRI scans, blood tests, eye examinations, etc., performed during the various stages of the disease course. “I firmly believe – continues Paul – that this approach will allow us to greatly improve the quality of life and the prognosis of people with MS”. Also part of the project is the idea of developing an app that allows patients to regularly write down information about their symptoms, as well as the costs they have to incur for treatment.
AI reveals the hidden face of multiple sclerosis
by Tiziana Moriconi
Multiple sclerosis: many treatments and no cure
Multiple sclerosis (MS) is a disease caused by an uncontrolled response by the immune system, which attacks the brain and spinal cord, progressively damaging them. It is a difficult disease to treat since at the moment there are no real cures, but only drugs used to improve its course. It is in fact a chronic neurodegenerative pathology, in which different forms are traditionally distinguished – broadly with relapses and remissions and progressive – and different symptoms, both motor and neurological, which upset the lives of patients. These can vary greatly from patient to patient, and often include balance and movement disorders in general, chronic fatigue unrelated to the activities performed, vision disorders, paroxysmal (i.e. violent and short-lived) or chronic pain, reduced sensitivity to the touch, intestinal disturbances, incontinence or urinary retention, loss of sensation in the genital area, cognitive disturbances, depression.
Multiple sclerosis, discovery of the indicator of the severity of the disease
by Letizia Gabaglio
The triggering causes are not yet known, but genetic factors certainly influence (the risk of developing MS increases if there are cases in the family) and some environmental factors: for example, the incidence of MS is higher in populations that live far from ‘equator. This is thought to be related to the level of sun exposure, as vitamin D deficiency (which the body synthesizes following exposure to solar radiation) has been identified as a risk factor for the development of the disease. Other environmental factors that appear to play a role in the onset of MS or worsening its course are cigarette smoking and obesity and Epstein-Barr infection.
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